A review on new natural and synthetic anti-leishmanial chemotherapeutic agents and current perspective of treatment approaches.
N Majumder, A Banerjee, S Saha - Acta Tropica, 2023 - Elsevier
Leishmaniases are considered among the most neglected yet dangerous parasitic diseases
worldwide. According to the recent WHO report (Weekly Epidemiological Record, Sep …
worldwide. According to the recent WHO report (Weekly Epidemiological Record, Sep …
Insights into the drug screening approaches in leishmaniasis
Leishmaniasis, a tropically neglected disease, is responsible for the high mortality and
morbidity ratio in poverty-stricken areas. Currently, no vaccine is available for the complete …
morbidity ratio in poverty-stricken areas. Currently, no vaccine is available for the complete …
[HTML][HTML] Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …
[HTML][HTML] The geroprotective drug candidate CMS121 alleviates diabetes, liver inflammation, and renal damage in db/db leptin receptor deficient mice
db/db mice, which lack leptin receptors and exhibit hyperphagia, show disturbances in
energy metabolism and are a model of obesity and type 2 diabetes. The geroneuroprotector …
energy metabolism and are a model of obesity and type 2 diabetes. The geroneuroprotector …
[HTML][HTML] HAS 1: A natural product from soil-isolated Streptomyces species with potent activity against cutaneous leishmaniasis caused by Leishmania tropica
Cutaneous Leishmaniasis (CL) is a neglected tropical disease, classified by the World
Health Organization (WHO) as one of the most unrestrained diseases. The Syrian war and …
Health Organization (WHO) as one of the most unrestrained diseases. The Syrian war and …
[HTML][HTML] Computer-aided drug design approaches applied to screen natural product's structural analogs targeting arginase in Leishmania spp
HL Barazorda-Ccahuana, LD Goyzueta-Mamani… - …, 2023 - ncbi.nlm.nih.gov
Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5
million new cases each year. Despite the new approaches and advances to fight the …
million new cases each year. Despite the new approaches and advances to fight the …
Thymoquinone Induced Leishmanicidal Effect via Programmed Cell Death in Leishmania donovani
Visceral leishmaniasis (VL) or kala-azar is a vector-borne dreaded protozoal infection that is
caused by the parasite Leishmania donovani. With increases in the dramatic infection rates …
caused by the parasite Leishmania donovani. With increases in the dramatic infection rates …
Flavonoids from Pistacia chinensis subsp. integerrima with leishmanicidal activity: computational and experimental evidence
Pistacia chinensis subsp. integerrima is a valuable medicinal plant as its parts and extracts
found application for treating diarrhea, fever, liver disorders, asthma, and inflammation. In …
found application for treating diarrhea, fever, liver disorders, asthma, and inflammation. In …
[HTML][HTML] Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates
Leishmaniasis is a tropical disease caused by a protozoan parasite Leishmania that is
transmitted via infected female sandflies. At present, leishmaniasis treatment mainly counts …
transmitted via infected female sandflies. At present, leishmaniasis treatment mainly counts …
[HTML][HTML] Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats
Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly
used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and …
used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and …