Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …

Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …

Following pathogen infection or tissue damage, the stimulation of pattern recognition
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …

Heat stress is one of the greatest challenges for the global livestock industries as increased
environmental temperature and humidity compromises animal production during summer …

Glucocorticoids (GCs) are endogenous hormones that are crucial for the homeostasis of the
organism and adaptation to the external environment. Because of their anti-inflammatory …

Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

It is estimated that 1 billion people around the world are vitamin D deficient. Vitamin D
deficiency has been linked to various inflammatory diseases. However, the mechanism by …

Reduced responsiveness to the anti-inflammatory effects of corticosteroids is a major barrier
to effective management of asthma in smokers and patients with severe asthma and in the …

Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

In response to physiological and psychogenic stressors, the hypothalamic–pituitary–adrenal
(HPA) axis orchestrates the systemic release of glucocorticoids (GCs). By virtue of nearly …