Importance A previous meta-analysis of the association between alcohol use and all-cause
mortality found no statistically significant reductions in mortality risk at low levels of …

Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic
cardiovascular disease (ASCVD). According to a widely cited model, HDL elicits its …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

OBJECTIVES: To systematically summarize the risk relationship between different levels of
alcohol consumption and incidence of liver cirrhosis. METHODS: MEDLINE and Embase …

Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …

Importance Depression is a common mental health disorder in the US. Depressive
symptoms have been associated with increased cardiovascular disease incidence and …

Importance Soft drinks are frequently consumed, but whether this consumption is associated
with mortality risk is unknown and has been understudied in European populations to date …

Abstract The Healthy Eating Index-2005 (HEI-2005) measures adherence to the 2005
Dietary Guidelines for Americans, but the association between the HEI-2005 and risk of …

In high-income countries, the biggest cause of premature death, defined as death before 70
years, is smoking of manufactured cigarettes. Smoking-related disease was responsible for …

Increased attention in dietary research and guidance has been focused on dietary patterns,
rather than on single nutrients or food groups, because dietary components are consumed …