PET parametric imaging: past, present, and future
Positron emission tomography (PET) is actively used in a diverse range of applications in
oncology, cardiology, and neurology. The use of PET in the clinical setting focuses on static …
oncology, cardiology, and neurology. The use of PET in the clinical setting focuses on static …
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis
B Selvarajah, I Azuelos, D Anastasiou… - Science Signaling, 2021 - science.org
Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis
PT Lukey, SA Harrison, S Yang, Y Man… - European …, 2019 - Eur Respiratory Soc
Phosphatidylinositol 3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) play a
role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Omipalisib (GSK2126458) is …
role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Omipalisib (GSK2126458) is …
Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury
PZ Mannes, CE Barnes, J Biermann… - Proceedings of the …, 2023 - National Acad Sciences
The lack of techniques for noninvasive imaging of inflammation has challenged precision
medicine management of acute respiratory distress syndrome (ARDS). Here, we determined …
medicine management of acute respiratory distress syndrome (ARDS). Here, we determined …
Shape Anisotropy‐Governed High‐Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs
Caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), coronavirus
disease 2019 (COVID‐19) has shown extensive lung manifestations in vulnerable …
disease 2019 (COVID‐19) has shown extensive lung manifestations in vulnerable …
Total-body PET kinetic modeling and potential opportunities using deep learning
PET is a sensitive molecular imaging method that uses radiolabeled tracers to monitor the
biological and physiologic function of the scanned subject in vivo. 1 PET is commonly used …
biological and physiologic function of the scanned subject in vivo. 1 PET is commonly used …
Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)
Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …
A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a …
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with
poor prognosis and a significant unmet medical need. This study evaluated the safety …
poor prognosis and a significant unmet medical need. This study evaluated the safety …
Pulmonary 18F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF)
Purpose There is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF)
patients. The objective of this study is to investigate the potential of 18 F-FDG-PET/CT to …
patients. The objective of this study is to investigate the potential of 18 F-FDG-PET/CT to …
High-temporal-resolution lung kinetic modeling using total-body dynamic PET with time-delay and dispersion corrections
Tracer kinetic modeling in dynamic PET has the potential to improve the diagnosis,
prognosis, and research of lung diseases. The advent of total-body PET systems with much …
prognosis, and research of lung diseases. The advent of total-body PET systems with much …