Introduction Chronic inflammatory diseases include cardiovascular disease (CVD),
atherosclerosis, rheumatic and autoimmune diseases, and others, constituting a large part of …

Atherosclerosis and its main consequence, cardiovascular disease (CVD) are nowadays
regarded as chronic inflammatory disease conditions, and CVD is the main cause of death …

Objective—Modifications of lipid constituents within atherosclerotic lesions generate
neoepitopes that activate innate and adaptive immune responses. We aimed to define the …

Background and aims Observational studies have demonstrated that the pneumococcal
polysaccharide vaccine (PPV) is associated with reduced risk of cardiovascular events. This …

Background Phosphorylcholine (PC) is an important pro‐inflammatory damage‐associated
molecular pattern. Previous data have shown that natural IgM anti‐PC protects against …

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by
venous, arterial or microvascular thrombosis or obstetric events in the presence of …

Abstract Background Low concentrations of IgM-phosphorylcholine autoantibodies (IgM-anti-
PC) have been shown to be associated with increased risk of incident cardiovascular …

Sudden cardiac death (SCD) is the leading cause of death worldwide. Myocardial ischemia
(MI) is the most common underlying causal disorder for SCD. Metabolic risks leading to SCD …

Background The increased risk of cardiovascular events (CVE) in rheumatoid arthritis (RA)
is not fully explained by traditional risk factors. Immuno-inflammatory mechanisms and …

Background Antibodies against cardiolipin and phosphatidylserine (anti-CL and anti-PS) are
associated with thrombosis. In contrast, we determined that IgM antibodies against oxidized …