Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data

Z Pang, G Zhou, J Ewald, L Chang, O Hacariz… - Nature protocols, 2022 - nature.com
Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …

Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Metabolomics and isotope tracing

C Jang, L Chen, JD Rabinowitz - Cell, 2018 - cell.com
Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …

Changes in volatile flavor of yak meat during oxidation based on multi-omics

Q Huang, K Dong, Q Wang, X Huang, G Wang, F An… - Food Chemistry, 2022 - Elsevier
Hydroxyl radical system combined with GC-IMS and metabolomics were used to assess the
effect of oxidation on the formation of volatile flavor emitted from yak meat. The formation of …

[HTML][HTML] Effect of ultrasound combined with exogenous GABA treatment on polyphenolic metabolites and antioxidant activity of mung bean during germination

L Wang, X Li, F Gao, Y Liu, S Lang, C Wang… - Ultrasonics …, 2023 - Elsevier
Mung bean seeds were treated by a combination of ultrasound and γ-aminobutyric acid
(GABA). Effect of these treatments on the free polyphenols content, antioxidant activity, and …

Metabolite measurement: pitfalls to avoid and practices to follow

W Lu, X Su, MS Klein, IA Lewis, O Fiehn… - Annual review of …, 2017 - annualreviews.org
Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis

R Sun, Z Zhang, R Bao, X Guo, Y Gu, W Yang, J Wei… - Journal of …, 2022 - Elsevier
Background & Aims The liver is a metabolically active organ and is also 'tolerogenic',
exhibiting sophisticated mechanisms of immune regulation that prevent pathogen attacks …

Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases

L Cui, H Lu, YH Lee - Mass spectrometry reviews, 2018 - Wiley Online Library
In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …

Quality assurance procedures for mass spectrometry untargeted metabolomics. a review

D Dudzik, C Barbas-Bernardos, A García… - … of pharmaceutical and …, 2018 - Elsevier
Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan

DQ Chen, G Cao, H Chen, CP Argyopoulos… - Nature …, 2019 - nature.com
Early detection and accurate monitoring of chronic kidney disease (CKD) could improve
care and retard progression to end-stage renal disease. Here, using untargeted …