The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular
homeostasis due to its key functions in the one-carbon cycle, which include methionine and …

We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

The endothelium plays important roles in modulating vascular tone by synthesizing and
releasing a variety of endothelium-derived relaxing factors, including vasodilator …

Endothelial activation and dysfunction is an important contributor to atherosclerosis,
cardiovascular diseases and cardiorenal syndrome. Endothelial dysfunction is also linked …

The aim of this updated statement is to provide comprehensive and timely evidence-based
recommendations on the prevention of stroke among individuals who have not previously …

The aim of this updated guideline is to provide comprehensive and timely evidence-based
recommendations on the prevention of future stroke among survivors of ischemic stroke or …

Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Abstract The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is
associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) …

An increasing aging population worldwide accounts for a growing share of
noncommunicable diseases (NCDs) of the overall social and economic burden. Dietary and …