Strengthening molecular glues: design strategies for improving thalidomide analogs as cereblon effectors and anticancer agents
MJ Nutt, SG Stewart - Drug Discovery Today, 2024 - Elsevier
Highlights•SAR insights on minimum pharmacophore for CRBN binding.•Scaffold alterations
improving drug solubility and stability.•Rational approaches: phenotypic screening, target …
improving drug solubility and stability.•Rational approaches: phenotypic screening, target …
Synthesis, antifungal activity, 3D-QSAR, and molecular docking study of novel menthol-derived 1, 2, 4-triazole-thioether compounds
M Huang, WG Duan, GS Lin, BY Li - Molecules, 2021 - mdpi.com
A series of novel menthol derivatives containing 1, 2, 4-triazole-thioether moiety were
designed, synthesized, characterized structurally, and evaluated biologically to explore …
designed, synthesized, characterized structurally, and evaluated biologically to explore …
Synthetic and Pharmacological Investigations of Therapeutically Relevant N-Heterocycles
M Nutt - 2022 - research-repository.uwa.edu.au
This thesis details the study of several interesting and underexplored classes of N-
heterocycles with value to the field of medicinal chemistry and drug discovery. These …
heterocycles with value to the field of medicinal chemistry and drug discovery. These …