The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

A high-fat diet (HFD) induces changes in gut microbiota leading to activation of pro-
inflammatory pathways, and obesity, as a consequence of overnutrition, exacerbates …

Epidemiological and experimental studies have revealed strong associations between
dietary lipids and cancer risk. However, the molecular mechanisms underlying the effects of …

A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1),
a universally expressed fatty acid Δ9-desaturase that converts saturated fatty acids (SFA) …

Breast cancer has been confirmed to have lipid disorders in the tumour microenvironment.
Peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated …

Metabolic reprogramming is a key hallmark of cancer, but less is known about metabolic
plasticity of the same tumor at different sites. Here, we investigated the metabolic adaptation …

Dysregulated fatty acid metabolism interacts with oncogenic signals, thereby worsening
tumor aggressiveness. The stearoyl-CoA desaturating enzymes, SCD1 and SCD5, convert …

Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the
field of cancer due to their potential role in its prevention and treatment. MUFAs can be …