Nowadays, epigenetics is of great research value as a new gateway that can solve the
sophisticated mysteries behind neurodegenerative diseases. Epigenetic mechanisms …

BET proteins function as histone code readers of acetylated lysins that determine the
positive regulation in transcription of genes involved in cell cycle progression, differentiation …

Communication between astrocytes and neurons has a profound effect on the
pathophysiology of Alzheimer's disease (AD). Astrocytes regulate homeostasis and increase …

Background Aging, a complex and profound journey, leads us through a labyrinth of
physiological and pathological transformations, rendering us increasingly susceptible to …

Background: Epigenetic regulation of gene signalling is one of the fundamental molecular
mechanisms for the generation and maintenance of cellular memory. Histone acetylation is …

After long times of ongoing research, still there is no appropriate cure for Alzheimer's
disease (AD). Recently, epigenetic alterations, particularly miRNA, have gotten attention in …

This study evaluated the effect of intra-hippocampal injection of JQ1 on cognitive deficiency
and protein level of c-Fos and brain-derived neurotrophic factor (BDNF) in the hippocampus …

Wingless-type family members (Wnt5a) and secreted frizzled-related protein 5 (SFRP5) play
important roles in the central nervous system during development. However, the effects of …

Aging is the greatest known risk factor for Alzheimer's Disease (AD); however, the molecular
mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown …

Abstract Objectives Metabolic syndrome (MetS) is a serious concern among
postmenopausal women which predisposes them to cardiovascular and cognitive disorders …