Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and
individuals under 45 year age. A wide variety of cellular and molecular mechanisms have …

Alzheimer's disease (AD) is one of the most common causes of neurodegenerative diseases
in the elderly. The accumulation of amyloid‐β (Aβ) peptides is one of the pathological …

Transient receptor potential (TRP) channels are a family of cation channels that depolarizes
the membrane potential and regulates intracellular concentrations of cations such as Ca 2+ …

Neuronal activity can be modulated by mechanical stimuli. To study this phenomenon
quantitatively, we mechanically stimulated rat cortical neurons by shear stress and local …

Numerous neurodegenerative diseases result from altered ion channel function and
mutations. The intracellular redox status can significantly alter the gating characteristics of …

Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

Store-operated calcium entry (SOCE) is the flow of calcium ions (Ca 2+) into cells in
response to the depletion of intracellular Ca 2+ stores that reside predominantly in the …

Background and Purpose Psychedelics elicit prosocial, antidepressant and anxiolytic effects
via neuroplasticity, neurotransmission and neuro‐immunomodulatory mechanisms. Whether …

Calcium is an important second messenger required not only for the excitation-contraction
coupling of the heart but also critical for the activation of cell signaling pathways involved in …