[HTML][HTML] Cryptococcus neoformans adapts to the host environment through TOR-mediated remodeling of phospholipid asymmetry
Cryptococcus spp. are environmental fungi that first must adapt to the host environment
before they can cause life-threatening meningitis in immunocompromised patients. Host …
before they can cause life-threatening meningitis in immunocompromised patients. Host …
[HTML][HTML] Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans
YH Li, TB Liu - International journal of molecular sciences, 2020 - mdpi.com
Zinc is one of the essential trace elements in eukaryotes and it is a critical structural
component of a large number of proteins. Zinc finger proteins (ZNFs) are zinc-finger domain …
component of a large number of proteins. Zinc finger proteins (ZNFs) are zinc-finger domain …
[HTML][HTML] The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases
every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans …
every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans …
The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans
VE Glazier, JC Panepinto - Virulence, 2014 - Taylor & Francis
In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under
stress conditions. During temperature adaptation in the human fungal pathogen …
stress conditions. During temperature adaptation in the human fungal pathogen …
The F-Box Protein Fbp1 Shapes the Immunogenic Potential of Cryptococcus neoformans
Cryptococcus neoformans is the main etiologic agent of cryptococcal meningitis and causes
a significant number of deadly infections per year. Although it is well appreciated that host …
a significant number of deadly infections per year. Although it is well appreciated that host …
The ZIP family zinc transporters support the virulence of Cryptococcus neoformans
Zinc is an essential element in living organisms and a cofactor for various metalloproteins.
To disseminate and survive, a pathogenic microbe must obtain zinc from the host, which is …
To disseminate and survive, a pathogenic microbe must obtain zinc from the host, which is …
Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans
Amino acid biosynthetic pathways that are absent in mammals are considered an attractive
target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of …
target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of …
Host carbon dioxide concentration is an independent stress for Cryptococcus neoformans that affects virulence and antifungal susceptibility
The ability of Cryptococcus neoformans to cause disease in humans varies significantly
among strains with highly related genotypes. In general, environmental isolates of …
among strains with highly related genotypes. In general, environmental isolates of …
[HTML][HTML] The Vacuolar Morphogenesis Protein Vam6-Like Protein Vlp1 Is Required for Pathogenicity of Cryptococcus neoformans
CL Fan, TB Liu - Journal of Fungi, 2021 - mdpi.com
Cryptococcus neoformans is an encapsulated yeast pathogen that infects
immunocompromised patients to cause fungal meningitis, resulting in hundreds of …
immunocompromised patients to cause fungal meningitis, resulting in hundreds of …
[HTML][HTML] Multiple F-Box Proteins Collectively Regulate Cell Development and Pathogenesis in the Human Pathogen Cryptococcus neoformans
The ubiquitin–proteasome system (UPS) mediates intracellular proteins degradation that
influences various cellular functions in eukaryotic cells. The UPS is also involved in the …
influences various cellular functions in eukaryotic cells. The UPS is also involved in the …