Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

PD-1, a T cell checkpoint receptor and target of cancer immunotherapy, is also expressed on
myeloid cells. The role of myeloid-specific versus T cell–specific PD-1 ablation on antitumor …

While the understanding of the genomic aberrations that underpin chronic and acute
myeloid leukaemia (CML and AML) has allowed the development of therapies for these …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Inflammation-adapted hematopoietic stem and progenitor cells (HSPCs) have long been
appreciated as key drivers of emergency myelopoiesis, thereby enabling the bone marrow …

Increasing evidence implicates metabolic pathways as key regulators of cell fate and
function. Although the metabolism of glucose, amino acids, and fatty acids is essential to …

During vertebrate embryogenesis, fetal hematopoietic stem and progenitor cells (HSPCs)
exhibit expansion and differentiation properties in a supportive hematopoietic niche. To …

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-
renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate …

Hematopoietic stem cells (HSCs) have reduced capacities to properly maintain and
replenish the hematopoietic system during myelosuppressive injury or aging. Expanding …