Diabetes is a chronic metabolic disease that is increasing in prevalence and causes many
complications. Diabetic cardiomyopathy (DCM) is a complication of diabetes that is …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Small‑molecule chemical drugs are of great significance for tumor‑targeted and
individualized therapies. However, the development of new small‑molecule drugs, from …

Empagliflozin (EMPA) therapy has led to improvements in patients with non-alcoholic fatty
liver disease (NAFLD). Sestrin2 is a stress-inducible protein that controls the AMPK-mTOR …

Macroautophagy/autophagy is a lysosome-dependent catabolic pathway for the degradation
of intracellular proteins and organelles. Autophagy dysfunction is related to many diseases …

Sestrins are stress-responsive proteins with antioxidant properties. They participate in
cellular redox balance and protect against oxidative damage. This study investigated the …

Inflammation is a complex physiological phenomenon, which is the body's defensive
response, but abnormal inflammation can have adverse effects, and many diseases are …

Diabetic cardiomyopathy is a critical diabetes-mediated co-morbidity characterized by
cardiac dysfunction and heart failure, without predisposing hypertensive or atherosclerotic …

Objective Alterations in intestinal function play a crucial role in the pathogenesis of sepsis,
and the repair of the intestinal barrier is a potential strategy for the treatment of sepsis …

In this study, we aimed to determine whether liraglutide could effectively reduce insulin
resistance (IR) by regulating Sestrin2 (SESN2) expression in L6 rat skeletal muscle cells by …