Angiotensin II-induced signal transduction mechanisms for cardiac hypertrophy

SK Bhullar, NS Dhalla - Cells, 2022 - mdpi.com
Although acute exposure of the heart to angiotensin (Ang II) produces physiological cardiac
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …

Involvement of oxidative stress in the development of subcellular defects and heart disease

NS Dhalla, V Elimban, M Bartekova, A Adameova - Biomedicines, 2022 - mdpi.com
It is now well known that oxidative stress promotes lipid peroxidation, protein oxidation,
activation of proteases, fragmentation of DNA and alteration in gene expression for …

Cardiac side effects of RNA‐based SARS‐CoV‐2 vaccines: hidden cardiotoxic effects of mRNA‐1273 and BNT162b2 on ventricular myocyte function and structure

R Schreckenberg, N Woitasky, N Itani… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose To protect against SARS‐CoV‐2 infection, the first mRNA‐
based vaccines, Spikevax (mRNA‐1273, Moderna) and Comirnaty (BNT162b2 …

Importance of mitochondria in cardiac pathologies: focus on uncoupling proteins and monoamine oxidases

R Schulz, KD Schlüter - International Journal of Molecular Sciences, 2023 - mdpi.com
On the one hand, reactive oxygen species (ROS) are involved in the onset and progression
of a wide array of diseases. On the other hand, these are a part of signaling pathways …

Fibroblasts and the extracellular matrix in right ventricular disease

NG Frangogiannis - Cardiovascular research, 2017 - academic.oup.com
Right ventricular failure predicts adverse outcome in patients with pulmonary hypertension
(PH), and in subjects with left ventricular heart failure and is associated with interstitial …

Oxidized low-density lipoprotein (oxLDL) affects load-free cell shortening of cardiomyocytes in a proprotein convertase subtilisin/kexin 9 (PCSK9)-dependent way

KD Schlüter, A Wolf, M Weber… - Basic research in …, 2017 - Springer
Recent studies have documented that oxidized low-density lipoprotein cholesterol (oxLDL)
levels directly impact myocardial structure and function. However, the molecular …

Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure

J Heger, R Schulz, G Euler - British Journal of Pharmacology, 2016 - Wiley Online Library
Cardiac hypertrophy is a mechanism to compensate for increased cardiac work load, that is,
after myocardial infarction or upon pressure overload. However, in the long run cardiac …

Exploring functional differences between the right and left ventricles to better understand right ventricular dysfunction

J Bernal-Ramirez, MC Díaz-Vesga… - Oxidative Medicine …, 2021 - Wiley Online Library
The right and left ventricles have traditionally been studied as individual entities.
Furthermore, modifications found in diseased left ventricles are assumed to influence on …

Stem cell therapy for hypoplastic left heart syndrome: mechanism, clinical application, and future directions

GJ Bittle, D Morales, KB Deatrick, N Parchment… - Circulation …, 2018 - Am Heart Assoc
Hypoplastic left heart syndrome is a type of congenital heart disease characterized by
underdevelopment of the left ventricle, outflow tract, and aorta. The condition is fatal if …

Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart

A Wrobeln, KD Schlüter, J Linders… - Artificial cells …, 2017 - Taylor & Francis
The aim of this study was to prove whether albumin-derived perfluorocarbon-based
nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff …