Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Deep brain stimulation (DBS) is a therapeutic option for intractable neurological and
psychiatric disorders, including Parkinson's disease and major depression. Because of the …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

The popularity of caffeine as a psychoactive drug is due to its stimulant properties, which
depend on its ability to reduce adenosine transmission in the brain. Adenosine A 1 and A 2A …

A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

1 A degree of ambiguity and uncertainty exists concerning the distribution of mRNAs
encoding the four cloned adenosine receptors. In order to consolidate and extend current …

The possible molecular basis for the previously described antagonistic interactions between
adenosine A1 receptors (A1R) and dopamine D1 receptors (D1R) in the brain have been …

The A2A adenosine receptor (A2A‐AR) transcript and radioligand binding sites have a
distinct distribution in rat brain, restricted primarily to the striatum, nucleus accumbens and …

Caffeine is the most widely consumed, behaviorally active substance in the world. Average
caffeine consumption in humans can range in different cultures and nations from 80 to 400 …