The caspase (Casp) family of proteases regulate both lymphocyte apoptosis and activation.
Here, we show that Casp6 regulates early B‐cell development. One‐week‐old Casp6 …

As we age, our bodies lose the ability to repair damaged tissues. This impairment may be
due to age-related deficits in our regenerative stem cells. Stem cells reside in specialized …

Polycythemia vera (PV) is a myeloproliferative disorder involving hematopoietic stem cells. A
recurrent somatic missense mutation in JAK2 (JAK2V617F) is thought to play a causal role …

6.1 In vivo reconstitution dynamics 48 6.1. 1 HSPC frequencies in the stem cell grafts 48 6.1.
2 Drawbacks in achieving experimental baseline conditions 49 6.1. 3 Lentiviral transduction …

GYQYAJJFPNQOOW-UHFFFAOYSA-N gilteritinib Chemical compound N1= C
(NC2CCOCC2) C (CC)= NC (C (N)= O)= C1NC (C= C1OC)= CC= C1N (CC1) CCC1N1CCN …

Zeb1, a zinc finger E-box binding EMT transcription factor, acts as a critical regulator of cell
plasticity and confers properties of 'stemness', such as self-renewal, in cancer. Yet little is …

La Cardiotrophin-Like Cytokine (CLCF1) est une cytokine de la famille de l'IL-6 connue
principalement pour ses fonctions neurotrophiques médiées par l'activation du récepteur au …

Aging of the hematopoietic system is associated with various blood disorders in the elderly.
Potential benefits of transplantation using compatible donor hematopoietic stem cells cannot …

Aggressive B-cell lymphomas are diverse group of neoplasms that arise at different stages
of B-cell development and by various mechanisms of neoplastic transformation. Aggressive …

PRDM16 is a transcriptional co-regulator that is highly expressed in HSCs and required for
their maintenance. It is also involved in translocations in acute myeloid leukemia (AML) …