The mechanisms that control localization of marginal zone (MZ) B cells are poorly
understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 …

Chemokines are a large family of small, generally secreted polypeptides which guide
lymphocyte movement throughout the body by controlling integrin avidity and inducing …

Chemokines orchestrate leukocyte trafficking and function in health and disease.
Heterophilic interactions between chemokines in a given microenvironment may amplify …

The omentum is a site of B1 cell lymphopoiesis and immune responsiveness to T cell-
independent antigens. However, it is unknown whether it supports immune responses …

Peritoneal B1 cells are known to generate large amounts of antibodies outside their
residential site. These antibodies play an important role in the early defense against bacteria …

Background A major current challenge is to exploit tertiary lymphoid structures (TLSs) to
promote the lymphocyte infiltration, activation and differentiation by tumor antigens to …

Directed cellular migrations underlie immune system organization. Chemokines and their
receptors (along with surface‐adhesion molecules) are central to these migrations, targeting …

CXCL13 is a homeostatic chemokine for lymphocyte homing and positioning within follicles
of secondary lymphoid tissues, acting through its cognate receptor, CXCR5. Moreover, the …

The factors regulating dendritic cell (DC) development and homeostasis are incompletely
understood. Here, we demonstrate that DCs express the lymphotoxin (LT)-β receptor (LTβR) …

Specific metabolic programs are activated by immune cells to fulfill their functional roles,
which include adaptations to their microenvironment. B1 B cells are tissue-resident, innate …