Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …

In the past decade, the idea that single populations of neurons support cognition and
behavior has gradually given way to the realization that connectivity matters and that …

Background Binge alcohol drinking is a risk factor linked to numerous disease states
including alcohol use disorder (AUD). While men binge drink more alcohol than women, this …

Background High-level alcohol consumption causes neuroplastic changes in the brain that
promote pathological drinking behavior. Some of these changes have been characterized in …

The effects of context on the subjective experience of serotonergic psychedelics have not
been fully examined in human neuroimaging studies, partly due to limitations of the imaging …

Rationale Over the last decade, oxycodone has become one of the most widely abused
drugs in the USA. Oxycodone use disorder (OUD) is a serious health problem that has …

Many fundamental questions on alcohol use disorder (AUD) are frequently difficult to
address by examining a single brain structure, but should be viewed from the whole brain …

Alcohol use disorder (AUD) is frequently comorbid with mood disorders, and these co-
occurring neuropsychiatric disorders contribute to the development and maintenance of …

Studies using rodent models have shown that relapse to drug or food seeking increases
progressively during abstinence, a behavioral phenomenon termed “incubation of craving.” …