Cells under stress: the mechanical environment shapes inflammasome responses to danger signals
H Joshi, SC Morley - Journal of Leukocyte Biology, 2019 - academic.oup.com
Many intracellular signals, such as host danger-associated molecules and bacterial toxins
during infection, elicit inflammasome activation. However, the mechanical environment in …
during infection, elicit inflammasome activation. However, the mechanical environment in …
Alpha1-antitrypsin deficiency and cardiovascular disease: questions and issues of a debated relation
L Pini, J Giordani, M Ciarfaglia, A Pini… - Journal of …, 2022 - journals.lww.com
Abstract Alpha1-antitrypsin (AAT) is one of the major inhibitors involved in
protease/antiprotease homeostasis, and it is mainly produced by hepatocytes and …
protease/antiprotease homeostasis, and it is mainly produced by hepatocytes and …
Severe α1-antitrypsin deficiency associated with lower blood pressure and reduced risk of ischemic heart disease: a cohort study of 91,540 individuals and a meta …
SV Winther, D Ahmed, S Al-Shuweli, EM Landt… - Respiratory …, 2022 - Springer
Background Increased elastase activity in α1-antitrypsin deficiency may affect elasticity of
the arterial walls, and thereby blood pressure and susceptibility to cardiovascular disease …
the arterial walls, and thereby blood pressure and susceptibility to cardiovascular disease …
High rate of abdominal aortic calcification in COPD patients and its relationship with musculoskeletal fragility
RQ Graumam, MM Pinheiro, VL Szejnfeld… - Osteoporosis …, 2023 - Springer
A very high rate of abdominal aortic calcification was observed in patients with COPD.
Vascular calcification severity was associated with older age and lower bone mass at the …
Vascular calcification severity was associated with older age and lower bone mass at the …
Alpha-1 antitrypsin deficiency and accelerated aging: a new model for an old disease?
D Crossley, R Stockley, E Sapey - Drugs & aging, 2019 - Springer
Abstract Alpha-1 antitrypsin (AAT) protects the lung by inhibiting neutrophil proteinases, but
AAT has many other non-proteolytic functions that are anti-inflammatory, antiviral and …
AAT has many other non-proteolytic functions that are anti-inflammatory, antiviral and …
Cardiovascular disease in Alpha 1 antitrypsin deficiency: an observational study assessing the role of neutrophil proteinase activity and the suitability of validated …
Abstract Background Alpha 1 Antitrypsin Deficiency (AATD) is a rare, inherited lung disease
which shares features with Chronic Obstructive Pulmonary Disease (COPD) but has a …
which shares features with Chronic Obstructive Pulmonary Disease (COPD) but has a …
Close association between subclinical atherosclerosis and pulmonary function in middle-aged male smokers
T Sugiura, Y Dohi, Y Takagi, T Yokochi… - … of Atherosclerosis and …, 2020 - jstage.jst.go.jp
Aims: Cigarette smoking provokes deleterious influences on cardiovascular and pulmonary
systems, although the underlying relationship has not been sufficiently investigated …
systems, although the underlying relationship has not been sufficiently investigated …
Quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD
L Vass, M Fisk, J Cheriyan, D Mohan… - ERJ Open …, 2021 - Eur Respiratory Soc
Rationale COPD and smoking are characterised by pulmonary inflammation. 18F-
fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) …
fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) …
Factors affecting brain structure in smoking-related diseases: Chronic Obstructive Pulmonary Disease (COPD) and coronary artery disease
CA Spilling, MPK Dhillon, DR Burrage, S Ruickbie… - Plos one, 2021 - journals.plos.org
Background Changes in brain structure and cognitive decline occur in Chronic Obstructive
Pulmonary Disease (COPD). They also occur with smoking and coronary artery disease …
Pulmonary Disease (COPD). They also occur with smoking and coronary artery disease …
[HTML][HTML] Atherosclerotic Coronary Plaque Features in Patients with Chronic Obstructive Pulmonary Disease and Acute Coronary Syndrome
M Russo, M Camilli, G La Vecchia, R Rinaldi… - The American Journal of …, 2024 - Elsevier
Previous studies reported a robust relationship between chronic obstructive pulmonary
disease (COPD) and coronary artery disease (CAD). Systemic inflammation has been …
disease (COPD) and coronary artery disease (CAD). Systemic inflammation has been …