Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …

Individual MHC genotype constrains the mutational landscape during tumorigenesis.
Immune checkpoint inhibition reactivates immunity against tumors that escaped immune …

Effective vaccines induce high-affinity memory B cells and durable antibody responses
through accelerated mechanisms of natural selection. Secondary changes in antibody …

Abstract Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key
role in antigen recognition during the adaptive immune response. Recent progress in next …

B cells produce a diverse antibody repertoire by undergoing gene rearrangements.
Pathogen exposure induces the clonal expansion of B cells expressing antibodies that can …

Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction
of this population. A key aspect of antibody-mediated anti-influenza virus immunity is …

Influenza is a global public health problem. Current seasonal influenza vaccines have highly
variable efficacy, and thus attempts to develop broadly protective universal influenza …

Measles is a disease caused by the highly infectious measles virus (MeV) that results in both
viremia and lymphopenia. Lymphocyte counts recover shortly after the disappearance of …

High-throughput sequencing analysis of hypermutating immunoglobulin (IG) repertoires
remains a challenging task. Here we present a robust protocol for the full-length profiling of …

High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative
analysis of adaptive immune responses and offers the potential to revolutionize research in …