From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”
M Bulati, C Caruso, G Colonna-Romano - Ageing research reviews, 2017 - Elsevier
Ageing is a complex process characterized by a general decline in physiological functions
with increasing morbidity and mortality. The most important aspect of ageing is the chronic …
with increasing morbidity and mortality. The most important aspect of ageing is the chronic …
[HTML][HTML] Estimating the life course of influenza A (H3N2) antibody responses from cross-sectional data
The immunity of a host population against specific influenza A strains can influence a
number of important biological processes, from the emergence of new virus strains to the …
number of important biological processes, from the emergence of new virus strains to the …
The diversity and molecular evolution of B-cell receptors during infection
B-cell receptors (BCRs) are membrane-bound immunoglobulins that recognize and bind
foreign proteins (antigens). BCRs are formed through random somatic changes of germline …
foreign proteins (antigens). BCRs are formed through random somatic changes of germline …
High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination
YC Tan, LK Blum, S Kongpachith, CH Ju, X Cai… - Clinical …, 2014 - Elsevier
We developed a DNA barcoding method to enable high-throughput sequencing of the
cognate heavy-and light-chain pairs of the antibodies expressed by individual B cells. We …
cognate heavy-and light-chain pairs of the antibodies expressed by individual B cells. We …
[HTML][HTML] Aging, social distancing, and COVID-19 risk: Who is more vulnerable and why?
J Faraji, GAS Metz - Aging and disease, 2021 - ncbi.nlm.nih.gov
Perceived social support represents an important predictor of healthy aging. The global
COVID-19 pandemic has dramatically changed the face of social relationships and revealed …
COVID-19 pandemic has dramatically changed the face of social relationships and revealed …
Quantitative profiling of immune repertoires for minor lymphocyte counts using unique molecular identifiers
ES Egorov, EM Merzlyak, AA Shelenkov… - The Journal of …, 2015 - journals.aai.org
Emerging high-throughput sequencing methods for the analyses of complex structure of
TCR and BCR repertoires give a powerful impulse to adaptive immunity studies. However …
TCR and BCR repertoires give a powerful impulse to adaptive immunity studies. However …
[HTML][HTML] Inferring cell-state transition dynamics from lineage trees and endpoint single-cell measurements
As they proliferate, living cells undergo transitions between specific molecularly and
developmentally distinct states. Despite the functional centrality of these transitions in …
developmentally distinct states. Despite the functional centrality of these transitions in …
Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody
Broadly neutralizing antibodies (bnAbs) that neutralize diverse variants of a particular virus
are of considerable therapeutic interest. Recent advances have enabled us to isolate and …
are of considerable therapeutic interest. Recent advances have enabled us to isolate and …
[HTML][HTML] In-depth assessment of within-individual and inter-individual variation in the B cell receptor repertoire
High-throughput sequencing of the B cell receptor (BCR) repertoire can provide rapid
characterization of the B cell response in a wide variety of applications in health, after …
characterization of the B cell response in a wide variety of applications in health, after …
[HTML][HTML] Analysis of B cell repertoire dynamics following hepatitis B vaccination in humans, and enrichment of vaccine-specific antibody sequences
Generating a diverse B cell immunoglobulin repertoire is essential for protection against
infection. The repertoire in humans can now be comprehensively measured by high …
infection. The repertoire in humans can now be comprehensively measured by high …