Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

MULTIPLE MYELOMA (MM) is a clonal B-cell neo-plasm that affects terminally differentiated
B cells (ie, plasma cells) and may proceed through different phases: an inactive phase in …

Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and permeability
factor that is potently angiogenic in vivo. We report here studies that suggest that VEGF …

Publisher Summary This chapter focuses on the proteins of the Myc network that are
essential regulators of cell growth and differentiation. The identification of the Myc partner …

Abstract Objective Peripheral blood lymphocytes (PBLs) from systemic lupus erythematosus
(SLE) patients exhibit increased spontaneous and diminished activation‐induced apoptosis …

Activation of the cell surface receptor Fas/APO‐1 (CD95) induces apoptosis in lymphocytes
and regulates immune responses. The cytoplasmic membrane protein Bcl‐2 inhibits …

In humans and experimental models of renal ischemia, tubular cells in various nephron
segments undergo necrotic and/or apoptotic cell death. Various factors, including nucleotide …

Apoptosis, a mechanism for programmed cell death, has key roles in human health and
disease. Many signals for cellular life and death are regulated by the BCL-2 family proteins …

Formation of the male gamete occurs in sequential mitotic, meiotic, and postmeiotic phases.
Many germ cell-specific transcripts are produced during this process. Their expression is …

Interdigital cell death leads to regression of soft tissue between embryonic digits in many
vertebrates. Although the signals that regulate interdigital apoptosis are not known, BMPs …