Cerebral ischemia: from animal studies to clinical practice. Should the methods be reviewed?
MA de Leciñana, E Díez-Tejedor, F Carceller… - Cerebrovascular …, 2001 - karger.com
The development of experimental models of focal cerebral ischemia has allowed for a better
knowledge of its pathophysiology and for testing therapeutic strategies. However, most …
knowledge of its pathophysiology and for testing therapeutic strategies. However, most …
A comparative study of variables influencing ischemic injury in the Longa and Koizumi methods of intraluminal filament middle cerebral artery occlusion in mice
The intraluminal filament model of middle cerebral artery occlusion (MCAO) in mice and rats
has been plagued by inconsistency, owing in part to the multitude of variables requiring …
has been plagued by inconsistency, owing in part to the multitude of variables requiring …
Assessment of Cerebral Blood Flow and CO2 Reactivity after Controlled Cortical Impact by Perfusion Magnetic Resonance Imaging using Arterial Spin-Labeling in …
ML Forbes, KS Hendrich… - Journal of Cerebral …, 1997 - journals.sagepub.com
We measured CBF and CO2 reactivity after traumatic brain injury (TBI) produced by
controlled cortical impact (CCI) using magnetic resonance imaging (MRI) and spin-labeled …
controlled cortical impact (CCI) using magnetic resonance imaging (MRI) and spin-labeled …
Comparison of pH-state and alpha-stat cardiopulmonary bypass on cerebral oxygenation and blood flow in relation to hypothermic circulatory arrest in piglets
DC Kurth, MM O'Rourke, IB O'Hara - The Journal of the American …, 1998 - pubs.asahq.org
Background Deep hypothermic circulatory arrest is used in neonatal cardiac surgery. Recent
work has suggested improved neurologic recovery after deep hypothermic arrest with pH …
work has suggested improved neurologic recovery after deep hypothermic arrest with pH …
Protective effects of memantine against ischemia-reperfusion injury in spontaneously hypertensive rats
A Dogan, MA Eras, VL Raghavendra Rao… - Acta …, 1999 - Springer
Memantine, an uncompetitive NMDA open-channel blocker, has been shown to be effective
in preventing neuronal damage after permanent focal cerebral ischemia. Reperfusion after a …
in preventing neuronal damage after permanent focal cerebral ischemia. Reperfusion after a …
Nitrite infusion increases cerebral blood flow and decreases mean arterial blood pressure in rats: a role for red cell NO
JM Rifkind, E Nagababu, E Barbiro-Michaely… - Nitric Oxide, 2007 - Elsevier
It has been proposed that the reduction of nitrite by red cells producing NO plays a role in
the regulation of vascular tone. This hypothesis was investigated in rats by measuring the …
the regulation of vascular tone. This hypothesis was investigated in rats by measuring the …
Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation
R Gedeborg, HC Silander… - Critical care …, 2000 - journals.lww.com
Objective: To study the effects of high-dose epinephrine, compared with standard-dose
epinephrine, on the dynamics of superficial cortical cerebral blood flow as well as global …
epinephrine, on the dynamics of superficial cortical cerebral blood flow as well as global …
Cerebral ischaemia in experimental cardiopulmonary resuscitation—comparison of epinephrine and aortic occlusion
R Gedeborg, C Hans, S Rubertsson, L Wiklund - Resuscitation, 2001 - Elsevier
The apparent inability of epinephrine to improve outcome after cardiopulmonary
resuscitation (CPR) could be caused by direct negative effects on the cerebral circulation …
resuscitation (CPR) could be caused by direct negative effects on the cerebral circulation …
Cortical infarct volume is dependent on the ischemic reduction of perifocal cerebral blood flow in a three-vessel intraluminal MCA occlusion/reperfusion model in the …
MA Soriano, O Sanz, I Ferrer, AM Planas - Brain research, 1997 - Elsevier
Occlusion of the middle cerebral artery (MCA) causes a reduction of cerebral blood flow
(CBF), which shows a progressive decrease from the periphery to the core of the MCA …
(CBF), which shows a progressive decrease from the periphery to the core of the MCA …
A rat model of endothelin-3-induced middle cerebral artery occlusion with controlled reperfusion
DC Henshall, SP Butcher, J Sharkey - Brain research, 1999 - Elsevier
Surge hyperemia and mechanical damage to the cerebrovascular endothelium may serve to
exacerbate the neuropathological outcome in animal models of focal cerebral ischemia. We …
exacerbate the neuropathological outcome in animal models of focal cerebral ischemia. We …