On the specificity of protein–protein interactions in the context of disorder

K Teilum, JG Olsen, BB Kragelund - Biochemical Journal, 2021 - portlandpress.com
With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …

Improving the hole picture: towards a consensus on the mechanism of nuclear transport

D Cowburn, M Rout - Biochemical Society Transactions, 2023 - portlandpress.com
Nuclear pore complexes (NPCs) mediate the exchange of materials between the
nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and …

Graphene sensor arrays for rapid and accurate detection of pancreatic cancer exosomes in patients' blood plasma samples

T Yin, L Xu, B Gil, N Merali, MS Sokolikova… - ACS …, 2023 - ACS Publications
Biosensors based on graphene field effect transistors (GFETs) have the potential to enable
the development of point-of-care diagnostic tools for early stage disease detection …

[HTML][HTML] Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core

AJ Pak, A Yu, Z Ke, JAG Briggs, GA Voth - Nature communications, 2022 - nature.com
The molecular events that permit the spike glycoprotein of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) to bind and enter cells are important to understand …

Avidity-based method for the efficient generation of monoubiquitinated recombinant proteins

SL Nelson, Y Li, Y Chen… - Journal of the American …, 2023 - ACS Publications
Monoubiquitination of proteins governs diverse physiological processes, and its
dysregulation is implicated in multiple pathologies. The difficulty of preparing sufficient …

Synthetic star nanoengineered antimicrobial polymers as antibiofilm agents: Bacterial membrane disruption and cell aggregation

S Laroque, R Garcia Maset, A Hapeshi… - …, 2023 - ACS Publications
Antimicrobial resistance has become a worldwide issue, with multiresistant bacterial strains
emerging at an alarming rate. Multivalent antimicrobial polymer architectures such as bottle …

Accelerated evolution by diversity-generating retroelements

BR Macadangdang, SK Makanani… - Annual review of …, 2022 - annualreviews.org
Diversity-generating retroelements (DGRs) create vast amounts of targeted, functional
diversity by facilitating the rapid evolution of ligand-binding protein domains. Thousands of …

[HTML][HTML] Searching for the secret of stickiness: How biofilms adhere to surfaces

Z Jiang, T Nero, S Mukherjee, R Olson… - Frontiers in …, 2021 - frontiersin.org
Bacterial biofilms are communities of cells enclosed in an extracellular polymeric matrix in
which cells adhere to each other and to foreign surfaces. The development of a biofilm is a …

Supramolecular “click chemistry” for targeting in the body

CJ Addonizio, BD Gates, MJ Webber - Bioconjugate chemistry, 2021 - ACS Publications
The fields of precision imaging and drug delivery have revealed a number of tools to
improve target specificity and increase efficacy in diagnosing and treating disease …

[HTML][HTML] Multimericity amplifies the synergy of BCR and TLR4 for B cell activation and antibody class switching

EJ Pone, JE Hernandez-Davies, S Jan… - Frontiers in …, 2022 - frontiersin.org
Sustained signaling through the B cell antigen receptor (BCR) is thought to occur only when
antigen (s) crosslink or disperse multiple BCR units, such as by multimeric antigens found …