On the specificity of protein–protein interactions in the context of disorder
With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …
interactomes, the question about their specificity—or more so on their multispecificity—arise …
Improving the hole picture: towards a consensus on the mechanism of nuclear transport
Nuclear pore complexes (NPCs) mediate the exchange of materials between the
nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and …
nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and …
Graphene sensor arrays for rapid and accurate detection of pancreatic cancer exosomes in patients' blood plasma samples
T Yin, L Xu, B Gil, N Merali, MS Sokolikova… - ACS …, 2023 - ACS Publications
Biosensors based on graphene field effect transistors (GFETs) have the potential to enable
the development of point-of-care diagnostic tools for early stage disease detection …
the development of point-of-care diagnostic tools for early stage disease detection …
[HTML][HTML] Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core
The molecular events that permit the spike glycoprotein of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) to bind and enter cells are important to understand …
syndrome coronavirus 2 (SARS-CoV-2) to bind and enter cells are important to understand …
Avidity-based method for the efficient generation of monoubiquitinated recombinant proteins
Monoubiquitination of proteins governs diverse physiological processes, and its
dysregulation is implicated in multiple pathologies. The difficulty of preparing sufficient …
dysregulation is implicated in multiple pathologies. The difficulty of preparing sufficient …
Synthetic star nanoengineered antimicrobial polymers as antibiofilm agents: Bacterial membrane disruption and cell aggregation
Antimicrobial resistance has become a worldwide issue, with multiresistant bacterial strains
emerging at an alarming rate. Multivalent antimicrobial polymer architectures such as bottle …
emerging at an alarming rate. Multivalent antimicrobial polymer architectures such as bottle …
Accelerated evolution by diversity-generating retroelements
BR Macadangdang, SK Makanani… - Annual review of …, 2022 - annualreviews.org
Diversity-generating retroelements (DGRs) create vast amounts of targeted, functional
diversity by facilitating the rapid evolution of ligand-binding protein domains. Thousands of …
diversity by facilitating the rapid evolution of ligand-binding protein domains. Thousands of …
[HTML][HTML] Searching for the secret of stickiness: How biofilms adhere to surfaces
Z Jiang, T Nero, S Mukherjee, R Olson… - Frontiers in …, 2021 - frontiersin.org
Bacterial biofilms are communities of cells enclosed in an extracellular polymeric matrix in
which cells adhere to each other and to foreign surfaces. The development of a biofilm is a …
which cells adhere to each other and to foreign surfaces. The development of a biofilm is a …
Supramolecular “click chemistry” for targeting in the body
CJ Addonizio, BD Gates, MJ Webber - Bioconjugate chemistry, 2021 - ACS Publications
The fields of precision imaging and drug delivery have revealed a number of tools to
improve target specificity and increase efficacy in diagnosing and treating disease …
improve target specificity and increase efficacy in diagnosing and treating disease …
[HTML][HTML] Multimericity amplifies the synergy of BCR and TLR4 for B cell activation and antibody class switching
EJ Pone, JE Hernandez-Davies, S Jan… - Frontiers in …, 2022 - frontiersin.org
Sustained signaling through the B cell antigen receptor (BCR) is thought to occur only when
antigen (s) crosslink or disperse multiple BCR units, such as by multimeric antigens found …
antigen (s) crosslink or disperse multiple BCR units, such as by multimeric antigens found …