Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy

B Zhao, H Li, Y Xia, Y Wang, Y Wang, Y Shi… - Journal of Hematology & …, 2022 - Springer
Immunotherapy for cancer is a rapidly developing treatment that modifies the immune
system and enhances the antitumor immune response. B7-H3 (CD276), a member of the B7 …

New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

AA Getu, A Tigabu, M Zhou, J Lu, Ø Fodstad, M Tan - Molecular Cancer, 2023 - Springer
Abstract B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …

Disulfidptosis-associated LncRNAs index predicts prognosis and chemotherapy drugs sensitivity in cervical cancer

L Liu, J Liu, Q Lyu, J Huang, Y Chen, C Feng, Y Liu… - Scientific reports, 2023 - nature.com
Disulfidptosis is a newly discovered form of cell death. Not yet clearly classified as
programmed cell death or accidental cell death. This study aimed to create a novel …

B7-H4, a promising target for immunotherapy

JY Wang, WP Wang - Cellular Immunology, 2020 - Elsevier
The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally
expressed in tumors, inflammation and autoimmune diseases. B7-H4 negatively regulates T …

News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors

O Melaiu, V Lucarini, R Giovannoni, D Fruci… - Seminars in cancer …, 2022 - Elsevier
Immune checkpoint inhibitors (ICIs) have shown unprecedented benefits in various adult
cancers, and this success has prompted the exploration of ICI therapy even in childhood …

B7-H3 immune checkpoint protein in human cancer

K Flem-Karlsen, Ø Fodstad… - Current medicinal …, 2020 - ingentaconnect.com
B7-H3 belongs to the B7 family of immune checkpoint proteins, which are important
regulators of the adaptive immune response and emerging key players in human cancer. B7 …

The role of B7-H3 in tumors and its potential in clinical application

R Feng, Y Chen, Y Liu, Q Zhou, W Zhang - International …, 2021 - Elsevier
Abstract B7-H3 (CD276 molecule) is an immune checkpoint from the B7 family of molecules
that acts more as a co-inhibitory molecule to promote tumor progression. It is abnormally …

[HTML][HTML] Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy

L Yu, M Sun, Q Zhang, Q Zhou, Y Wang - Frontiers in immunology, 2022 - frontiersin.org
With the goal of harnessing the host's immune system to provide long-lasting remission and
cures for various cancers, the advent of immunotherapy revolutionized the cancer therapy …

B7-H3 induces ovarian cancer drugs resistance through an PI3K/AKT/BCL-2 signaling pathway

L Zhou, Y Zhao - Cancer management and research, 2019 - Taylor & Francis
Purpose This study was aimed to investigate the underlying mechanism of B7-H3 induced
ovarian cancer proliferation and drugs resistance. Materials and methods We compared the …

[HTML][HTML] Expression of B7 family checkpoint proteins in cervical cancer

L Zong, Y Gu, Y Zhou, Y Kong, S Mo, S Yu, Y Xiang… - Modern Pathology, 2022 - Elsevier
The role of programmed cell death-ligand 1 (PD-L1) in cervical cancer has been widely
investigated; however, the influences of other inhibitory B7 family members are poorly …