Hormonal crosstalk between thyroid and breast cancer
S Halada, V Casado-Medrano, JA Baran, J Lee… - …, 2022 - academic.oup.com
Differentiated thyroid cancer and breast cancer account for a significant portion of endocrine-
related malignancies and predominately affect women. As hormonally responsive tissues …
related malignancies and predominately affect women. As hormonally responsive tissues …
Links between breast and thyroid cancer: Hormones, genetic susceptibility and medical interventions
M Lu, H Liu, B Zheng, S Sun, C Chen - Cancers, 2022 - mdpi.com
Simple Summary Breast and thyroid cancer are commonly diagnosed in women. Physicians
have recognized and evaluated the phenomenon of two cancers occurring synchronously or …
have recognized and evaluated the phenomenon of two cancers occurring synchronously or …
Exploiting vitamin D receptor and its ligands to target squamous cell carcinomas of the head and neck
L Koll, D Gül, MI Elnouaem, H Raslan… - International journal of …, 2023 - mdpi.com
Vitamin D (VitD) and its receptor (VDR) have been intensively investigated in many cancers.
As knowledge for head and neck cancer (HNC) is limited, we investigated the (pre) clinical …
As knowledge for head and neck cancer (HNC) is limited, we investigated the (pre) clinical …
Cytoplasmic localization of rxrα determines outcome in breast cancer
A Zati Zehni, F Batz, V Cavaillès, S Sixou, T Kaltofen… - Cancers, 2021 - mdpi.com
Simple Summary Considering the immense development of today's therapeutic approaches
in oncology towards customized therapy, this study aimed to assess the prognostic value of …
in oncology towards customized therapy, this study aimed to assess the prognostic value of …
Low thyroid hormone receptor alpha-2 (THRα-2) tumor expression is associated with unfavorable tumor characteristics and high breast cancer mortality
M Sandsveden, S Borgquist, AH Rosendahl… - Breast Cancer …, 2021 - Springer
Background The active thyroid hormone triiodothyronine (T3) has been found to have an
estrogen-like effect on breast cancer cells. Thyroid hormone receptor alpha-2 (THRα-2) acts …
estrogen-like effect on breast cancer cells. Thyroid hormone receptor alpha-2 (THRα-2) acts …
FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer
Estrogen receptor alpha (ER/ESR1) mutations occur in 30% to 40% of endocrine resistant
ER-positive (ER+) breast cancer. Forkhead box A1 (FOXA1) is a key pioneer factor …
ER-positive (ER+) breast cancer. Forkhead box A1 (FOXA1) is a key pioneer factor …
The clinical relevance of hypothyroidism in patients with solid non-thyroid cancer: a tantalizing conundrum
MV Deligiorgi, DT Trafalis - Journal of Clinical Medicine, 2022 - mdpi.com
Hypothyroidism in patients with solid non-thyroid cancer is a tantalizing entity, integrating an
intriguing thyroid hormones (THs)–cancer association with the complexity of hypothyroidism …
intriguing thyroid hormones (THs)–cancer association with the complexity of hypothyroidism …
Cytoplasmic localization of Thyroid Hormone Receptor (TR) alpha and nuclear expression of its isoform TRα2 determine survival in breast cancer in opposite ways
M Schneider, MB Köpke, AZ Zehni, T Vilsmaier… - Cancers, 2023 - mdpi.com
Simple Summary There is evidence of a link between breast cancer and thyroid disease.
Patients with thyroid dysfunction have an increased incidence of breast cancer compared to …
Patients with thyroid dysfunction have an increased incidence of breast cancer compared to …
TRα2—An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action?
GS Hönes, N Härting, J Mittag, FJ Kaiser - International journal of …, 2022 - mdpi.com
Thyroid hormones (THs) control a wide range of physiological functions essential for
metabolism, growth, and differentiation. On a molecular level, TH action is exerted by …
metabolism, growth, and differentiation. On a molecular level, TH action is exerted by …
Current understanding and distinct features of multifocal and multicentric breast cancers
E Avera, L Valentic, L Bui - Cancer Reports, 2023 - Wiley Online Library
Background Multifocal (MF) and multicentric (MC) breast cancers are referred to as
synchronous, multiple ipsilateral breast cancers; however, the definitions vary among the …
synchronous, multiple ipsilateral breast cancers; however, the definitions vary among the …