Increasing concerns about the rising rates of antibiotic therapy failure and advances in
single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial …

Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal
effects of antibiotic treatment, plays a critical and underappreciated role in the disease …

Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …

To combat the spread of antibiotic resistance, methods that quantitatively assess the
metabolism-inhibiting effects of drugs in a rapid and culture-independent manner are …

Adenosine triphosphate (ATP) is a universal mediator of metabolism and signaling across
unicellular and multicellular species. There is a fundamental interdependence between the …

In developmental biology, knowledge of cell structure and their (morpho) dynamic behavior,
leads to a comprehensive understanding of their conducts and the mechanisms in which …

A number of non-tuberculous mycobacterium species are opportunistic pathogens and
ubiquitously form biofilms. These infections are often recalcitrant to treatment and require …

Bioluminescence imaging of single cells is often complicated by the requirement of
exogenous luciferins that can be poorly cell-permeable or produce high background signal …

All indwelling and implantable medical devices are associated with a risk of infection, and
antimicrobial technologies that can provide effective protection against pathogen …

Highlights•Antibiotic lethality involves processes downstream of primary target
inhibition.•Respiration and altered metabolism actively participate in antibiotic lethality.• …