Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …

Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease of the central
nervous system (CNS) characterized by acute optic neuritis (ON) and transverse myelitis …

Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple
sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies …

Background and Objective There are few studies comparing lesion evolution across different
CNS demyelinating diseases, yet knowledge of this may be important for diagnosis and …

The understanding of neuromyelitis optica spectrum disorder (NMOSD) has evolved
substantially since its initial description over a century ago. The discovery in 2004 of a …

There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an autoimmune disease
of the nervous system first defined in 2016. GFAP autoantibody, especially IgG that binds to …

While neuromyelitis optica (NMO) immunoglobulin (Ig) G is considered the hallmark
serologic marker of NMO, its association is not absolute, as NMO IgG is not detected in …

Objective To compare response to rituximab (RTX) between adult patients positive for
myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies. Methods …