In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …

Language disorders are highly heritable and are influenced by complex interactions
between genetic and environmental factors. Despite more than twenty years of research, we …

O objetivo deste estudo consiste em reunir dados bibliográficos que descrevam o perfil
terapêutico do canabidiol (CBD), o principal componente não psicoativo da planta …

Neurodevelopmental disorders are multi-faceted and can lead to intellectual disability,
autism spectrum disorder and language impairment. Mutations in the Forkhead box FOXP1 …

Researchers are beginning to uncover the neurogenetic pathways that underlie our
unparalleled capacity for spoken language. Initial clues come from identification of genetic …

Development of proficient spoken language skills is disrupted by mutations of the FOXP2
transcription factor. A heterozygous missense mutation in the KE family causes speech …

Background De novo loss-of-function (dnLoF) mutations are found twofold more often in
autism spectrum disorder (ASD) probands than their unaffected siblings. Multiple …

Insights into the evolution of non-model organisms are limited by the lack of reference
genomes of high accuracy, completeness, and contiguity. Here, we present a chromosome …

Childhood maltreatment is highly prevalent and serves as a risk factor for mental and
physical disorders. Self-reported childhood maltreatment appears heritable, but the specific …