Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …

Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

A combination of different risk factors, such as genetic, environmental and psychological
factors, together with immune system, stress response, brain neuroplasticity and the …

The blood–brain barrier (BBB) is a complex vascular structure consisting of microvascular
endothelial cells that line the vessel wall, astrocyte end‐feet, pericytes, as well as the basal …

With the emergence of novel technologies and ground breaking concepts in BBB basic
research in the past decades, the researchers' attention on the critical role of blood brain …

As clinicians attempt to understand the underlying reasons for the vulnerability of different
regions of the developing brain to injury, it is apparent that little is known as to how hypoxia …

Background In the last two decades, there has been considerable evolution in
understanding the role of erythropoietin in neuroprotection. Erythropoietin has both …

Growing evidence of epidemiological, clinical and experimental studies has clearly shown a
close link between adverse in utero environment and the increased risk of neurological …

Therapeutic hypothermia (HT) is standard care for moderate and severe neonatal hypoxic-
ischaemic encephalopathy (HIE), the leading cause of permanent brain injury in term …

Objective To investigate the relationship between placental pathology and pattern of brain
injury in full-term infants with neonatal encephalopathy after a presumed hypoxic-ischemic …