Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
The why, how, and when of representations for complex systems
Complex systems, composed at the most basic level of units and their interactions, describe
phenomena in a wide variety of domains, from neuroscience to computer science and …
phenomena in a wide variety of domains, from neuroscience to computer science and …
[图书][B] Analysis of biological networks
BH Junker, F Schreiber - 2008 - Wiley Online Library
Analysis of biological networks ANALYSIS OF BIOLOGICAL NETWORKS Page 2
ANALYSIS OF BIOLOGICAL NETWORKS EDITED BY BJO RN H. JUNKER and FALK …
ANALYSIS OF BIOLOGICAL NETWORKS EDITED BY BJO RN H. JUNKER and FALK …
Structural and functional analysis of cellular networks with CellNetAnalyzer
S Klamt, J Saez-Rodriguez, ED Gilles - BMC systems biology, 2007 - Springer
Background Mathematical modelling of cellular networks is an integral part of Systems
Biology and requires appropriate software tools. An important class of methods in Systems …
Biology and requires appropriate software tools. An important class of methods in Systems …
Genome-scale metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome
Aspergillus fumigatus, an opportunistic human pathogen, frequently infects the lungs of
people with cystic fibrosis and is one of the most common causes of infectious-disease …
people with cystic fibrosis and is one of the most common causes of infectious-disease …
Modular epistasis in yeast metabolism
Epistatic interactions, manifested in the effects of mutations on the phenotypes caused by
other mutations, may help uncover the functional organization of complex biological …
other mutations, may help uncover the functional organization of complex biological …
A methodology for the structural and functional analysis of signaling and regulatory networks
S Klamt, J Saez-Rodriguez, JA Lindquist, L Simeoni… - BMC …, 2006 - Springer
Background Structural analysis of cellular interaction networks contributes to a deeper
understanding of network-wide interdependencies, causal relationships, and basic …
understanding of network-wide interdependencies, causal relationships, and basic …
Genome-scale models of bacterial metabolism: reconstruction and applications
M Durot, PY Bourguignon… - FEMS microbiology …, 2008 - academic.oup.com
Genome-scale metabolic models bridge the gap between genome-derived biochemical
information and metabolic phenotypes in a principled manner, providing a solid …
information and metabolic phenotypes in a principled manner, providing a solid …
Subgraph centrality and clustering in complex hyper-networks
E Estrada, JA Rodríguez-Velázquez - Physica A: Statistical Mechanics and …, 2006 - Elsevier
The representation of complex systems as networks is inappropriate for the study of certain
problems. We show several examples of social, biological, ecological and technological …
problems. We show several examples of social, biological, ecological and technological …