Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel
PT Nguyen, KR DeMarco, I Vorobyov… - Proceedings of the …, 2019 - National Acad Sciences
The human voltage-gated sodium channel, hNaV1. 5, is responsible for the rapid upstroke of
the cardiac action potential and is target for antiarrhythmic therapy. Despite the clinical …
the cardiac action potential and is target for antiarrhythmic therapy. Despite the clinical …
Structural modeling of hERG channel–drug interactions using Rosetta
AM Emigh Cortez, KR DeMarco, K Furutani… - Frontiers in …, 2023 - frontiersin.org
The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective
voltage-gated ion channel essential for normal electrical activity in the heart but is also a …
voltage-gated ion channel essential for normal electrical activity in the heart but is also a …
Pharmacokinetics and pharmacodynamics of intravenous agents for ventricular arrhythmias
PE Nolan Jr - … : The Journal of Human Pharmacology and Drug …, 1997 - Wiley Online Library
Although no antiarrhythmic agent has ideal pharmacokinetic and pharmacodynamic
characteristics, it is useful to evaluate antiarrhythmic agents in terms this ideal profile. The …
characteristics, it is useful to evaluate antiarrhythmic agents in terms this ideal profile. The …
Amiodarone-a 'broad spectrum'antiarrhythmic drug
SR Punnam, SK Goyal, VPK Kotaru… - … Current Drug Targets …, 2010 - ingentaconnect.com
Amiodarone, an iodinated benzofuran derivative, introduced in 1960's as an anti-anginal
agent, emerged as a potent anti-arrhythmic agent by 1970's and is currently one of the most …
agent, emerged as a potent anti-arrhythmic agent by 1970's and is currently one of the most …
Antiarrhythmic drugs
GW Abbott, R Levi - Pharmacology and Physiology for Anesthesia, 2019 - Elsevier
Disturbances in cardiac rhythm, also termed cardiac arrhythmias, can arise from structural
heart disease, adverse drug interactions, or inherited gene variants in ion channels or the …
heart disease, adverse drug interactions, or inherited gene variants in ion channels or the …
Structural modeling of hERG channel–drug interactions using Rosetta
K DeMarco, K Furutani, S Bekker, J Sack… - Frontiers in …, 2023 - europepmc.org
The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective
voltage-gated ion channel essential for normal electrical activity in the heart but is also a …
voltage-gated ion channel essential for normal electrical activity in the heart but is also a …
[图书][B] Structural Modeling of Voltage-Gated Ion Channel Interactions with Drugs Using Rosetta
AME Cortez - 2022 - search.proquest.com
Many different types of drugs–from antibiotics to blood pressure medication–tend to interfere
with the body's ability to control heart rhythm by disrupting the proteins in heart cells that …
with the body's ability to control heart rhythm by disrupting the proteins in heart cells that …
[HTML][HTML] QT prolongation and torsades de pointes during emergency treatment with nifekalant for refractory ventricular tachyarrhythmias: post-hoc analysis from a large …
T Katoh, S Ogawa, H Kasanuki - Journal of Arrhythmia, 2013 - Elsevier
Background Nifekalant, a first-line drug for the treatment of ventricular
tachycardia/ventricular fibrillation (VT/VF) in Japan, has been known to prolong the QT …
tachycardia/ventricular fibrillation (VT/VF) in Japan, has been known to prolong the QT …
The Effects of Lidocaine on Reperfusion Ventricular Fibrillation During Coronary Artery–Bypass Graft Surgery
Myocardial protection with cardioplegia has resulted in significant improvement in the
outcomes of cardiopulmonary bypass (CPB) in coronary artery-bypass graft (CABG) …
outcomes of cardiopulmonary bypass (CPB) in coronary artery-bypass graft (CABG) …
[PDF][PDF] The Effects of Lidocaine on Reperfusion Ventricular Fibrillation in Coronary Artery Bypass Graft Surgery
Myocardial protection with cardioplegia has resulted in significant improvement in the
outcomes of cardiopulmonary bypass (CPB) in coronary artery-bypass graft (CABG) …
outcomes of cardiopulmonary bypass (CPB) in coronary artery-bypass graft (CABG) …