Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Blood and urine biomarkers in osteoarthritis – an update on... : Current Opinion in Rheumatology
Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen …

The ultimate hope of researchers and patients is a pathway to development of treatments for
osteoarthritis to modify the disease process in addition to the symptoms. However …

Background Osteoarthritis (OA) is one of the most common age-related degenerative
diseases. In recent years, some studies have shown that pathological changes in the …

Purpose To provide an updated review of the literature on the use of orthobiologics as a
potential treatment option to alleviate symptoms associated with osteoarthritis (OA), slow the …

In recent years, markers research has focused on the structural components of cartilage
matrix. Specifically, a second generation of degradation markers has been developed …

Objective To provide an insightful summary of studies on biochemical markers for
osteoarthritis (OA). Design Two investigators systematically searched the electronic PubMed …

Background Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is
loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients …

Objective Osteoarthritis (OA) is characterized by the gradual loss of cartilage. Sprifermin, a
recombinant FGF18, is being developed as a cartilage anabolic drug. PRO-C2 is a serum …