Nanomaterial-based phototherapy has become an important research direction for cancer
therapy, but it still to face some obstacles, such as the toxic side effects and low target …

The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

The underlying cause of many metabolic diseases is abnormal changes in enzyme activity
in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; …

The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …

Proteins are central to life functions. Alterations in the structure of proteins are reflected in
their function. Misfolded proteins and their aggregates present a significant risk to the cell …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia,
memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic …

Ionic liquids (ILs) have been used in solvents for proteins in many applications, including
biotechnology, pharmaceutics, and medicine due to their tunable physicochemical and …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

It is still unclear why pathological amyloid deposition initiates in specific brain regions or why
some cells or tissues are more susceptible than others. Amyloid deposition is determined by …

Protein misfolding diseases (PMDs) are chronic and progressive, with no effective therapy
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …