Platinum drugs have been a mainstay of cancer chemotherapy since the introduction of
cisplatin in the 1970s. Since then, carboplatin and oxaliplatin have been approved world …

Abstract The utilization of Platinum (Pt)-based drugs has significantly transformed the
landscape of cancer chemotherapy, serving as highly effective anticancer agents. However …

We report herein the design, synthesis, and biological investigation of a series of novel Pt
(IV) prodrugs with non-steroidal anti-inflammatory drugs naproxen, diclofenac, and …

Introduction The trillions of microorganisms that comprise the gut microbiome form dynamic
bidirectional interactions with orally administered drugs and host health. These relationships …

Transition metal atoms possess the unique capacity to induce significant changes in the
electronic structure of their ligands, often culminating in substantial modification of their …

Cisplatin and its analogues are widely used as chemotherapeutic agents in clinical practice.
After being intravenously administrated, a substantial amount of platinum will bind with …

Human serum albumin (HSA) plays a major role in the transport of metallodrugs, affecting
pharmacokinetics and pharmacodynamics of these molecules. This work highlights the …

Simple Summary This study is one of the very few phase I trials on intraperitoneal
chemotherapy applied as PIPAC. Cisplatin and doxorubicin may be safely used as PIPAC at …

Background: Colorectal cancer (CRC) is a highly widespread malignancy and ranks as the
second most common cause of cancer-related mortality. Objective: Cancer patients …

Five new complexes of the palladium (II) ion (C1–C5) having the general formula [(PdL2)]
Cl2 with some 2-aminothiazoles (L1–L5), where L1= 2-amino-4-(3, 4-difluorophenyl) …