Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …

Lynch syndrome patients are susceptible to colorectal and endometrial cancers owing to
inactivating germline mutations in mismatch repair genes, including MSH2 (ref.). Here we …

The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …

Background & Aims: The revised Bethesda guidelines for Lynch syndrome recommend
microsatellite instability (MSI) testing all colorectal cancers in patients diagnosed before age …

Persons who have hypermethylation of one allele of MLH1 in somatic cells throughout the
body (a germ-line epimutation) have a predisposition for the development of cancer in a …

Background Microsatellite instability (MSI) causes hereditary non-polyposis colorectal
cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although …

Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to
hereditary cancer syndrome in human, but their transmission to offspring has never been …

It was shown that Lynch syndrome can be caused by germline hypermethylation of the
MLH1 and MSH2 promoters. Furthermore, it has been demonstrated very recently that …

Constitutional epimutations of tumor suppressor genes manifest as promoter methylation
and transcriptional silencing of a single allele in normal somatic tissues, thereby …