Zebrafish—A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers
D Roy, B Subramaniam, WC Chong, M Bornhorst… - Cancers, 2024 - mdpi.com
Simple Summary Cancer stands as the leading cause of death among children and
adolescents in the United States. Some of these pediatric cancers are highly aggressive and …
adolescents in the United States. Some of these pediatric cancers are highly aggressive and …
Promising animal models for amyotrophic lateral sclerosis drug discovery: a comprehensive update
L Lescouzères, SA Patten - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
characterized by the progressive loss of motor neurons. Several animal models have been …
characterized by the progressive loss of motor neurons. Several animal models have been …
ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons
P Zelina, AA de Ruiter, C Kolsteeg… - Acta neuropathologica …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease leading to
motor neuron loss. Currently mutations in> 40 genes have been linked to ALS, but the …
motor neuron loss. Currently mutations in> 40 genes have been linked to ALS, but the …
Advancements in 2D and 3D In Vitro Models for Studying Neuromuscular Diseases
H Kim, GS Kim, SH Hyun, E Kim - International Journal of Molecular …, 2023 - mdpi.com
Neuromuscular diseases (NMDs) are a genetically or clinically heterogeneous group of
diseases that involve injury or dysfunction of neuromuscular tissue components, including …
diseases that involve injury or dysfunction of neuromuscular tissue components, including …
Characterization of ClC‐1 chloride channels in zebrafish: a new model to study myotonia
H Gaitán‐Peñas, C Pérez‐Rius… - The Journal of …, 2024 - Wiley Online Library
The function of the chloride channel ClC‐1 is crucial for the control of muscle excitability.
Thus, reduction of ClC‐1 functions by CLCN1 mutations leads to myotonia congenita. Many …
Thus, reduction of ClC‐1 functions by CLCN1 mutations leads to myotonia congenita. Many …
NMJ Analyser: a novel method to quantify neuromuscular junction morphology in zebrafish
J Singh, YE Pan, SA Patten - Bioinformatics, 2023 - academic.oup.com
Motivation Neuromuscular junction (NMJ) structural integrity is crucial for transducing motor
neuron signals that initiate skeletal muscle contraction. Zebrafish has emerged as a simple …
neuron signals that initiate skeletal muscle contraction. Zebrafish has emerged as a simple …