Lipid metabolism in cancer progression and therapeutic strategies
Y Fu, T Zou, X Shen, PJ Nelson, J Li, C Wu, J Yang… - MedComm, 2021 - Wiley Online Library
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression
Abstract Background Circular RNAs (circRNAs) are stable, often highly expressed RNA
transcripts with potential to modulate other regulatory RNAs. A few circRNAs have been …
transcripts with potential to modulate other regulatory RNAs. A few circRNAs have been …
Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis
I Dotti, R Mora-Buch, E Ferrer-Picón, N Planell, P Jung… - Gut, 2017 - gut.bmj.com
Objective UC is a chronic inflammatory disease of the colonic mucosa. Growing evidence
supports a role for epithelial cell defects in driving pathology. Moreover, long-lasting …
supports a role for epithelial cell defects in driving pathology. Moreover, long-lasting …
Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer
Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …
Phospholipase A2 superfamily in cancer
Z Peng, Y Chang, J Fan, W Ji, C Su - Cancer Letters, 2021 - Elsevier
Phospholipase A2 enzymes (PLA 2 s) comprise a superfamily that is generally divided into
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …
Phospholipase signalling networks in cancer
JB Park, CS Lee, JH Jang, J Ghim, YJ Kim… - Nature Reviews …, 2012 - nature.com
Abstract Phospholipases (PLC, PLD and PLA) are essential mediators of intracellular and
intercellular signalling. They can function as phospholipid-hydrolysing enzymes that can …
intercellular signalling. They can function as phospholipid-hydrolysing enzymes that can …
The role of inflammatory mediators in colorectal cancer hepatic metastasis
Colorectal cancer (CRC) is the second leading cause of death in cancer patients in the USA,
whereas the major cause of CRC deaths is hepatic metastases. The liver is the most …
whereas the major cause of CRC deaths is hepatic metastases. The liver is the most …
Emerging roles for phospholipase A2 enzymes in cancer
Phospholipase A2 (PLA2) enzymes (EC3. 1.4. 4) regulate the release of biologically active
fatty acids and lysophospholipids from membrane phospholipid pools. These lipids are also …
fatty acids and lysophospholipids from membrane phospholipid pools. These lipids are also …
Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated …
K Zhu, L Cai, C Cui, JR de Los Toyos… - PLoS computational …, 2021 - journals.plos.org
During the last ten years, many research results have been referring to a particular type of
cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and …
cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and …