The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …

Antiviral immunity is initiated upon host recognition of viral products via non-self molecular
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …

Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection and its symptoms has been a pressing area of investigation during the …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

RNA viruses have evolved elaborate strategies to protect their genomes, including 5′
capping. However, until now no RNA 5′ cap has been identified for hepatitis C virus,(HCV) …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen
sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect …

Molecular virology tools are critical for basic studies of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental …

Host innate recognition triggers key immune responses for viral elimination. The sensing
mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream …

Infection of cells by microorganisms activates the inflammatory response. The initial sensing
of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll …