The interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown
considerably over the last decade due to its standardized production, long half-life of 78.2 h …

Simple Summary Chelators are small molecules that can form a complex with a metal ion by
coordinating electron rich atoms from the chelator to the electron-poor cation …

Purpose Currently, the most commonly used chelator for labelling antibodies with 89 Zr for
immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the …

The thermodynamic stability of a metal–ligand complex, as measured by the formation
constant (log β), is one of the most important parameters that determines metal ion selectivity …

This Tutorial Review aims to provide an overview of the use of zirconium-89 complexes in
biomedical imaging. Over the past decade there have been many new papers in this field …

Diagnostic molecular images, obtained by positron emission tomography (PET), have
successfully functioned as sensitive tools for detecting and monitoring the treatment of …

Thorium-227 (227Th) is an α-emitting radionuclide that has shown preclinical and clinical
promise for use in targeted α-therapy (TAT), a type of molecular radiopharmaceutical …

Over the last three decades, the chemistry of zirconium has facilitated antibody development
and the clinical management of disease in the precision medicine era. Scientists have …

One of the main challenges of PET imaging with 89 Zr-labeled monoclonal antibodies
(mAbs) remains the long blood circulation of the radiolabeled mAbs, leading to high …

Zirconium-89 (89Zr) is an ideal radiometal isotope for antibody-based positron emission
tomography (immunoPET) as its physical half-life (3.27 days) is a good match with the …