Abstract Carbohydrate antigen 19-9 (CA19-9) is the best validated biomarker and an
indicator of aberrant glycosylation in pancreatic cancer. CA19-9 functions as a biomarker …

Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Cancer is a deadly disease that encompasses numerous cellular modifications. Among
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Background Glycoproteins and glycolipids exist as an ensemble of glycosylated variants, or
glycoforms. Specific glycoforms are directly modulated by microenvironmental cues and play …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

Background The majority of human proteins are being modified by covalent attachment of
complex oligosaccharides—glycans. Both glycans and polypeptide parts of a protein …

The ability to inhibit the RAS oncogene has been the holy grail of oncology because of the
critical role of this gene in a multitude of tumor types. In addition, RAS-mutant tumors are …

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging is a rapidly
evolving field in which mass spectrometry techniques are applied directly on tissues to …

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to
drive tumour growth, metastasis and therapy resistance. It has recently been proposed that …