Production and bioactivity of oligosaccharides derived from lactose

M Villamiel, A Montilla, A Olano… - … Production, analysis and …, 2014 - Wiley Online Library
In an attempt to offer a broad overview on lactose applications as a source of bioactive
carbohydrates, in this chapter, the authors have collected the most recent investigations on …

[HTML][HTML] Expression of sialyl-Tn sugar antigen in bladder cancer cells affects response to Bacillus Calmette Guérin (BCG) and to oxidative damage

PF Severino, M Silva, M Carrascal, N Malagolini… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The sialyl-Tn (sTn) antigen is an O-linked carbohydrate chain aberrantly expressed in
bladder cancer (BC), whose biosynthesis is mainly controlled by the sialyltransferase …

CA19. 9 antigen circulating in the serum of colon cancer patients: where is it from?

L Mare, A Caretti, R Albertini, M Trinchera - The international journal of …, 2013 - Elsevier
CA19. 9 antigen is a glycoprotein present in human serum and found elevated in various
diseases. It is intensively studied since long time as a potential marker for managing cancers …

[HTML][HTML] Changes in plasma membrane surface potential of PC12 cells as measured by Kelvin probe force microscopy

CC Tsai, HH Hung, CP Liu, YT Chen, CY Pan - PLoS One, 2012 - journals.plos.org
The plasma membrane of a cell not only works as a physical barrier but also mediates the
signal relay between the extracellular milieu and the cell interior. Various stimulants may …

[HTML][HTML] Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer

Y Miyagawa, Y Matsushita… - International …, 2018 - spandidos-publications.com
Triple-negative breast cancer (TNBC), defined as breast cancer lacking estrogen-and
progesterone‑receptor expression and human epidermal growth factor receptor 2 (HER2) …

The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?

J Lv, J Wang, S Chang, M Liu… - Acta biochimica et …, 2016 - academic.oup.com
RAS oncogene mutations are frequently detected in human cancers. Among RAS-mediated
tumorigenesis, KRAS-driven cancers are the most frequently diagnosed and resistant to …

[HTML][HTML] Elucidating the multifaceted role of MGAT1 in hepatocellular carcinoma: integrative single-cell and spatial transcriptomics reveal novel therapeutic insights

Y Li, Y Chen, D Wang, L Wu, T Li, N An… - Frontiers in …, 2024 - frontiersin.org
Background Glycosyltransferase-associated genes play a crucial role in hepatocellular
carcinoma (HCC) pathogenesis. This study investigates their impact on the tumor …

Advancements in protein glycosylation biomarkers for ovarian cancer through mass spectrometry-based approaches

J Lee, JE Park, D Lee, N Seo, HJ An - Expert Review of Molecular …, 2024 - Taylor & Francis
Introduction Ovarian cancer, characterized by metastasis and reduced 5-year survival rates,
stands as a substantial factor in the mortality of gynecological malignancies worldwide. The …

Carbohydrate recognition by the antiviral lectin cyanovirin-N

YK Fujimoto, DF Green - Journal of the American Chemical …, 2012 - ACS Publications
Cyanovirin-N (CVN) is a cyanobacterial lectin with potent antiviral activity and has been the
focus of extensive preclinical investigation as a potential prophylactic for the prevention of …

[HTML][HTML] Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1

PF Severino, M Silva, M Carrascal, N Malagolini… - BMC cancer, 2018 - Springer
Abstract Background Treatment with Bacillus Calmette-Guérin (BCG) is the gold standard
adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in …