Aim/purpose Niclosamide (NCL) is an anthelminthic drug, which is widely used to treat
various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

In the current study, adult male zebrafish fed a normal diet (ND) or high-fat diet (HFD) were
exposed to niclosamide (NIC) at environmentally relevant concentrations to reveal the …

Drug repositioning may be defined as a process when new biological effects for known
drugs are identified, leading to recommendations for new therapeutic applications …

Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are
associated with cancer initiation, growth, and response to therapies. As concentrations …

Niclosamide is an anthelmintic drug that has been used for over 50 years mainly to treat
tapeworm infections. However, with the increase in drug repurposing initiatives, niclosamide …

Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …

Cancer poses a significant global health challenge, with predictions of increasing
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …

Triple negative breast cancer (TNBC) is the most dangerous subtype of breast cancer
accompanying by unfavorable prognosis due to lack of specific therapeutic targets …

The term 'magic bullet'is a scientific concept proposed by the German Nobel laureate Paul
Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease …