[HTML][HTML] Pyrazole and pyrazoline derivatives as antimalarial agents: A key review
Malaria poses a severe public health risk and a significant economic burden in disease-
endemic countries. One of the most severe issues in malaria control is the development of …
endemic countries. One of the most severe issues in malaria control is the development of …
[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
Synthesis and evaluation of 1, 3, 5-triaryl-2-pyrazoline derivatives as potent dual inhibitors of urease and α-glucosidase together with their cytotoxic, molecular …
In the present work, a concise library of 1, 3, 5-triaryl-2-pyrazolines (2a–2q) was designed
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
Identification of a new class of potent aldose reductase inhibitors: design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
Aldose reductase (AR) acts as a multi-disease target for the design and development of
therapeutic agents for the management of diabetic complications as well as non-diabetic …
therapeutic agents for the management of diabetic complications as well as non-diabetic …
Design and synthesis of carbothioamide/carboxamide-based pyrazoline analogs as potential anticancer agents: apoptosis, molecular docking, ADME assay, and DNA …
To discover anticancer drugs with novel structures and expand our research scope,
pyrazoline derivatives (3a–3l) were designed and synthesized through cyclization of …
pyrazoline derivatives (3a–3l) were designed and synthesized through cyclization of …
Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Sequential DNA-encoded building block fusion for the construction of polysubstituted pyrazoline core libraries
J Zhang, X Li, H Wei, Y Li, G Zhang, Y Li - Organic Letters, 2021 - ACS Publications
The construction of chemical libraries containing polysubstituted pyrazoline scaffolds is
highly desirable for the discovery of novel chemical ligands for biological targets. Herein, we …
highly desirable for the discovery of novel chemical ligands for biological targets. Herein, we …
Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling …
Here, we synthesized a newseries of mono-and bis (dimethylpyrazolyl)-s-triazine
derivatives. The synthetic methodology involved the reaction of different mono-and …
derivatives. The synthetic methodology involved the reaction of different mono-and …