[HTML][HTML] Apoe4 and Alzheimer's disease pathogenesis—Mitochondrial deregulation and targeted therapeutic strategies
M Pires, AC Rego - International Journal of Molecular Sciences, 2023 - mdpi.com
APOE ε4 allele (ApoE4) is the primary genetic risk factor for sporadic Alzheimer's disease
(AD), expressed in 40–65% of all AD patients. ApoE4 has been associated to many …
(AD), expressed in 40–65% of all AD patients. ApoE4 has been associated to many …
[HTML][HTML] REST and neural gene network dysregulation in iPSC models of Alzheimer's disease
The molecular basis of the earliest neuronal changes that lead to Alzheimer's disease (AD)
is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene …
is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene …
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
CR Muratore, HC Rice, P Srikanth… - Human molecular …, 2014 - academic.oup.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by
extracellular plaques containing amyloid β (Aβ)-protein and intracellular tangles containing …
extracellular plaques containing amyloid β (Aβ)-protein and intracellular tangles containing …
iPS cells: a game changer for future medicine
H Inoue, N Nagata, H Kurokawa, S Yamanaka - The EMBO journal, 2014 - embopress.org
The induced pluripotent stem cell (i PSC) technology is instrumental in advancing the fields
of disease modeling and cell transplantation. We herein discuss the various issues …
of disease modeling and cell transplantation. We herein discuss the various issues …
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
K Imamura, Y Izumi, A Watanabe, K Tsukita… - Science Translational …, 2017 - science.org
Amyotrophic lateral sclerosis (ALS), a fatal disease causing progressive loss of motor
neurons, still has no effective treatment. We developed a phenotypic screen to repurpose …
neurons, still has no effective treatment. We developed a phenotypic screen to repurpose …
[HTML][HTML] Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet
current therapeutic treatments are inadequate due to a complex disease pathogenesis. The …
current therapeutic treatments are inadequate due to a complex disease pathogenesis. The …
[HTML][HTML] Functionalization of brain region-specific spheroids with isogenic microglia-like cells
Current brain spheroids or organoids derived from human induced pluripotent stem cells
(hiPSCs) still lack a microglia component, the resident immune cells in the brain. The …
(hiPSCs) still lack a microglia component, the resident immune cells in the brain. The …
[HTML][HTML] Cellular functions of the amyloid precursor protein from development to dementia
R Van Der Kant, LSB Goldstein - Developmental cell, 2015 - cell.com
Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ
fragments of APP are the major constituent of AD-associated amyloid plaques, and …
fragments of APP are the major constituent of AD-associated amyloid plaques, and …
Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease involving aggregation
of misfolded proteins inside the neuron causing prolonged cellular stress. The …
of misfolded proteins inside the neuron causing prolonged cellular stress. The …
Hallmarks of Alzheimer's disease in stem-cell-derived human neurons transplanted into mouse brain
I Espuny-Camacho, AM Arranz, M Fiers, A Snellinx… - Neuron, 2017 - cell.com
Human pluripotent stem cells (PSCs) provide a unique entry to study species-specific
aspects of human disorders such as Alzheimer's disease (AD). However, in vitro culture of …
aspects of human disorders such as Alzheimer's disease (AD). However, in vitro culture of …