Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD),
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …
[HTML][HTML] Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives
F Oceguera-Yanez, SI Kim, T Matsumoto, GW Tan… - Methods, 2016 - Elsevier
The potential use of induced pluripotent stem cells (iPSCs) in personalized regenerative
medicine applications may be augmented by transgenics, including the expression of …
medicine applications may be augmented by transgenics, including the expression of …
Human iPSC-derived neural models for studying Alzheimer's disease: from neural stem cells to cerebral organoids
M Barak, V Fedorova, V Pospisilova, J Raska… - Stem Cell Reviews and …, 2022 - Springer
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …
to study mechanisms of human neural development, disease modeling, and drug discovery …
Dissecting the complexities of Alzheimer disease with in vitro models of the human brain
Alzheimer disease (AD) is the most prevalent type of dementia. It is marked by severe
memory loss and cognitive decline, and currently has limited effective treatment options …
memory loss and cognitive decline, and currently has limited effective treatment options …
Induced pluripotent stem cell (iPSC)-based neurodegenerative disease models for phenotype recapitulation and drug screening
Neurodegenerative diseases represent a significant unmet medical need in our aging
society. There are no effective treatments for most of these diseases, and we know …
society. There are no effective treatments for most of these diseases, and we know …
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
Three dimensional human neuro-spheroid model of Alzheimer's disease based on differentiated induced pluripotent stem cells
HK Lee, C Velazquez Sanchez, M Chen, PJ Morin… - PloS one, 2016 - journals.plos.org
The testing of candidate drugs to slow progression of Alzheimer's disease (AD) requires
clinical trials that are lengthy and expensive. Efforts to model the biochemical milieu of the …
clinical trials that are lengthy and expensive. Efforts to model the biochemical milieu of the …
iPS cell technologies: significance and applications to CNS regeneration and disease
H Okano, S Yamanaka - Molecular brain, 2014 - Springer
In 2006, we demonstrated that mature somatic cells can be reprogrammed to a pluripotent
state by gene transfer, generating induced pluripotent stem (iPS) cells. Since that time, there …
state by gene transfer, generating induced pluripotent stem (iPS) cells. Since that time, there …
Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
The use of iPSC derived brain organoid models to study neurodegenerative disease has
been hampered by a lack of systems that accurately and expeditiously recapitulate …
been hampered by a lack of systems that accurately and expeditiously recapitulate …
Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific …
Summary Niemann-Pick type C (NPC) disease is a fatal inherited lipid storage disorder
causing severe neurodegeneration and liver dysfunction with only limited treatment options …
causing severe neurodegeneration and liver dysfunction with only limited treatment options …