Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV)
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …

Viruses remain a global threat to animals, plants, and humans. The type 1 human
immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …

HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of
HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a …

Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay.
Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the …

Limited cellular levels of the HIV transcriptional activator Tat are one contributor to proviral
latency that might be targeted in HIV cure strategies. We recently demonstrated that lipid …

Combination antiretroviral therapy (ART) suppresses viral replication to undetectable levels,
reduces mortality and morbidity, and improves the quality of life of people living with HIV …

Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in
finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly …

The post-transcriptional processing and chemical modification of HIV RNA are understudied
aspects of HIV virology, primarily due to the limited ability to accurately map and quantify …

Introduction Heat shock protein (HSPs) are important intracellular factors, which are often
involved in the regulation of viral replication including HIV-1 in infected individuals as …

In the intricate dance between viruses and host cells, RNA-binding proteins (RBPs) serve as
crucial orchestrators of gene expression and cellular processes. We will delve into the …