Necrotizing enterocolitis: treatment based on staging criteria

MC Walsh, RM Kliegman - Pediatric Clinics of North America, 1986 - Elsevier
Neonatal necrotizing enterocolitis is the most important cause of acquired gastrointestinal
morbidity or mortality among low birthweight infants. Prematurity alone is probably the only …

Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness

RM Kliegman, MC Walsh - Current problems in pediatrics, 1987 - Elsevier
Although hundreds of new and important investigations have been published on the
epidemiology and pathophysiology of neonatal necrotizing enterocolitis (NEC) in the last …

Clostridium difficile: its disease and toxins

DM Lyerly, HC Krivan, TD Wilkins - Clinical microbiology reviews, 1988 - Am Soc Microbiol
Clostridium difficile is the etiologic agent of pseudomembranous colitis, a severe, sometimes
fatal disease that occurs in adults undergoing antimicrobial therapy. The disease, ironically …

Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC)

CJ Hunter, JS Upperman, HR Ford, V Camerini - Pediatric research, 2008 - nature.com
Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal
emergency encountered in the neonatal intensive care unit. Despite advances in neonatal …

Infectious causes of necrotizing enterocolitis

SA Coggins, JL Wynn… - Clinics in …, 2015 - perinatology.theclinics.com
NEC is a common and devastating problem for premature infants. Bacterial colonization
seems to be a necessary but not sufficient contributor to NEC. Although intestinal pathogens …

Source of human milk (mother or donor) is more important than fortifier type (human or bovine) in shaping the preterm infant microbiome

SV Kumbhare, WD Jones, S Fast, C Bonner… - Cell Reports …, 2022 - cell.com
Milk fortifiers help meet the nutritional needs of preterm infants receiving their mother's own
milk (MOM) or donor human milk. We conducted a randomized clinical trial (NCT03214822) …

Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development

T Raveh-Sadka, BC Thomas, A Singh, B Firek… - Elife, 2015 - elifesciences.org
Premature infants are highly vulnerable to aberrant gastrointestinal tract colonization, a
process that may lead to diseases like necrotizing enterocolitis. Thus, spread of potential …

Health care–associated infections in the neonatal intensive care unit

MT Brady - American journal of infection control, 2005 - Elsevier
Neonates represent a unique and highly vulnerable patient population. Advances in medical
technology that have occurred over the last few decades have improved the survival and …

The role of Clostridium difficile in the paediatric and neonatal gut — a narrative review

EA Lees, F Miyajima, M Pirmohamed… - European Journal of …, 2016 - Springer
Clostridium difficile is an important nosocomial pathogen in adults. Its significance in
children is less well defined, but cases of C. difficile infection (CDI) appear to be increasingly …

Changing epidemiology of Clostridium difficile-associated disease in children

L Benson, X Song, J Campos, N Singh - Infection Control & Hospital …, 2007 - cambridge.org
Objective. To determine temporal trends in the incidence rate for Clostridium difficile-
associated disease (CDAD) in a pediatric patient population. Methods. We performed an …