Simple Summary Soft tissue sarcomas (STSs) are rare malignant conditions with more than
70 subtypes that are difficult to treat, especially in advanced or metastatic states. Recently …

Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine
kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but …

Targeting cyclin-dependent kinase 7 (CDK7) has emerged as a highly sought-after
therapeutic strategy in oncology due to its duality of function in regulating biological …

Although cyclin-dependent kinase 2 (CDK2) is a validated target for both cancer and
contraception, developing a CDK2 inhibitor with exquisite selectivity has been challenging …

Abstract Cyclin-dependent kinase 9 (CDK9) plays a vital role in controlling cell transcription
and has been an attractive target for cancer treatment. Herein, ten predictive models derived …

Mono-N-methyl functionalization is one kind of important organic transformation, as mono N-
methylamines are present in a variety of pharmaceutical and agrochemical applications. The …

Metastasis remains the principal cause of cancer-related lethality despite advancements in
cancer treatment. Dysfunctional epigenetic alterations are crucial in the metastatic cascade …

Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and are frequently
altered in cancer cells, thereby leading to uncontrolled proliferation. In this context, CDK2 …

The duality of function (cell cycle regulation and gene transcription) of cyclin-dependent
kinase 7 (CDK7) makes it an attractive oncology target and the discovery of CDK7 inhibitors …

CDK8 plays a key role in acute myeloid leukemia, colorectal cancer and other cancers.
Here, a total of 54 compounds were designed and synthesized. Among them, the most …